Aciont’s Visulex® system potentially can combine the attributes of several different technologies which potentially will work efficiently in tandem yielding a safe, timely, non-invasive treatment for various diseases of the eye:

1. Visulex® scleral-lens shaped application device which improves drug delivery reproducibility by maintaining the drug reservoir on the same location on the eye’s conjunctival surface and minimizing solution leakage, exposure of the drug to the cornea and surface clearance effects.
2. Permeation enhancement formulation, an approach based upon reducing blood flow clearance effects and thereby increasing the residence time of the drug inside the target sites of the eye.
3. Our novel complexation method has demonstrated superior pharmacokinetic and efficacious results over conventionally formulated steroid prodrugs.
4. Other conventional formulations and drug delivery methods such as pharmaceutical carriers and formulations to deliver poorly water soluble drugs.
5. Our focused ocular iontophoresis method actively facilitates efficient localized drug diffusion across tissue barriers. Specially designed ocular surface electrodes produce an electrical field intraocularly within the patient’s eyeball, which transfers ionized drug formulations predominantly through the tissue or inside the eye as opposed to arbitrarily around the eye and/or surrounding localized tissues around the eye.

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Visulex® System Summary of Benefits Sample Illustrations IP Protection